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. 2016 Apr 4;8(5):511–526. doi: 10.15252/emmm.201505421

Figure 6. Prazosin inhibits glioblastoma growth in vivo in a PKCδ‐dependent manner.

Figure 6

  1. Schematic representation of the experimental design.
  2. Bioluminescent in vivo images of tumors in mice grafted with GICs expressing either scrambled (upper panel) or PKCδ (lower panel) shRNA. All mice were treated with prazosin (PRZ) for 45 days.
  3. Quantification of the bioluminescent signals showing that decreased expression of PKC counteracts prazosin inhibition of tumor growth. Fold change in total flux represents the ratio: total flux after treatment/total flux prior treatment. *P = 0.0007, n = 8, two‐sided Mann–Whitney U‐test.
  4. Schematic representation of the molecular mechanisms underlying prazosin‐induced GIC apoptosis. See text for details.