Figure 4.

A subset of F3 generation rats displays an augmented dopamine neuron population activity. F3 generation rats born from F2 methylazoxymethanol acetate (MAM) fathers display a significant increase in dopamine neuron population activity (a) when compared with F3 rats born from F2 saline parents. Interestingly, this phenotype was observed regardless of whether the F2 MAM father displayed an increase in dopamine neuron population activity (MAM (+)) or no change in activity (MAM (−)) (b). The percentage of F3 generation rats displaying a population activity ⩾1.5 is presented in c. ‡p=0.05 from F3 saline rats.