Figure 2.

Altered insula activity during visceral interoception in patients with anorexia nervosa. A region-of-interest analysis (voxel-wise threshold p<0.005, cluster size corrected for multiple comparisons at p<0.05) revealed two separate insula regions—the dorsal mid-insula and anterior insula—that exhibited a significant Group (AN, HC) × Interoceptive Modality (heart, stomach, bladder) interaction. The post hoc simple effects analyses revealed that the interaction in the dorsal mid-insula was because of group differences during stomach interoception (p<0.002, Bonferroni corrected), whereas in the anterior insula the interaction resulted from group differences during heart interoception (*p<0.03, Bonferroni corrected).