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. 2015 Jul 22;41(2):578–589. doi: 10.1038/npp.2015.186

Figure 1.

Figure 1

PNE reduced the density of glutamatergic neurons in the medial PFC. (a) Glutamate and GABA contents in the frontal cortex of control (n=14 at the age 10–12 weeks consists of seven males and seven females) and PNE prenatal nicotine exposure mice (n=12 at the age 10–12 weeks consists of five males and seven females). (b) Basal extracellular glutamate level and the high potassium (50 mM) stimulation-evoked glutamate release were measured in the PFC of control (n=8 at the age 12–16 weeks consists of four males and four females) and PNE mice (n=8 at the age 12–16 weeks consists of four males and four females). (c) NeuN- and GLS-immunostained coronal sections of the medial PFC in control and PNE mice. Quantitative analysis of the density of NeuN- and NeuN/GLS-stained cells was shown (n=11 for control mice at the age 10–12 weeks consists of four males and seven females, n=11 for PNE mice at the age 10–12 weeks consists of four males and seven females). Values are the means±SEM. *P<0.05, **P<0.01 vs corresponding control mice Scale bar: 100μm.