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. 2015 Jul 22;41(2):646–657. doi: 10.1038/npp.2015.195

Figure 5.

Figure 5

Choice between saccharin and a high dose of heroin in a continuous choice setting. (a) Within-session distribution of saccharin (0.2%) and heroin (0.08 mg per injection) when only one reward or both rewards were available during 10 h to the same representative individual rat. (b) Mean (±SEM) within-session time course of heroin (0.08 mg) rewards alone (no choice) or during continuous access to 0.2% saccharin (choice) (n=7). (c) Mean (±SEM) within-session time course of saccharin rewards alone or during continuous access to heroin (0.08 mg) (n=7). *Different from the ‘no choice' condition (p<0.01, main effect, ANOVA with repeated measures). (d) Mean (±SEM) saccharin rewards centered around all heroin injections. Time 0 indicates the onset of heroin injections. *Different from time 0 (p<0.05, Tukey's post hoc).