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| Passaged Replicate | KPT-1d | KPT-2 | KPT-3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Passage Number | 1 | 6 | 10 | 1 | 6 | 10 | 1 | 6 | 10 |
| Nucleotide changea | A7752T | A7752T | del 7742–7750 | A7751G | C7686T | ||||
| Amino acid changeb | K64M | K64M | del 61–63c | K64E | T41I | ||||
aNucleotide numbering is based on TC83 reference (Genbank Accession # L01443)
bAmino acid numbering is capsid-specific
cThree amino acid deletion is P-S-A
dTC83 passaged in the presence of DMSO did not yield any changes within the capsid ORF
