Table 5. Anthropometric and biochemical parameters as well as plasma Lf concentrations in a subsample of severely obese subjects matched for sex, age and BMI in high (n = 10) and low insulin sensitivity (n = 10) patients based on HOMA-IR.
| Variables | Insulin-sensitive subjects (Mean ± SD; n = 10) | Insulin-resistant subjects (Mean ± SD; n = 10) | Paired t-test(P values) |
|---|---|---|---|
| Anthropometrics | |||
| Sex (women/men) | 5/5 | 5/5 | - |
| BMI (kg/m2) | 52.0 ± 7.9 | 51.5 ± 7.2 | NS |
| Glucose homeostasis | |||
| Glycemia (mmol/L) | 5.44 ± 0.52 | 5.97 ± 0.65 | NS |
| Insulin (pmol/L) | 7.76 ± 3.02 | 51.43 ± 30.27 | 0.001 |
| HOMA-IR | 1.89 ± 0.73 | 13.77 ± 8.81 | 0.002 |
| Glycated hemoglobin (%) | 5.69 ± 0.002 | 5.92 ± 0.003 | 0.002 |
| Lipid profile (mmol/L) | |||
| Total cholesterol (mmol/L) | 4.34 ± 0.89 | 4.25 ± 1.36 | NS |
| Free cholesterol (mmol/L) | 1.32 ± 0.24 | 1.29 ± 0.42 | NS |
| Cholesterol ester (mmol/L) | 2.90 ± 0.74 | 2.75 ± 0.94 | NS |
| HDL cholesterol (mmol/L) | 1.37 ± 0.32 | 1.11 ± 0.27 | 0.004 |
| LDL cholesterol (mmol/L) | 2.53 ± 0.79 | 2.65 ± 0.89 | NS |
| Triglycerides (mmol/L) | 1.14 ± 0.38 | 1.86 ± 0.47 | 0.0003 |
| Totalcholesterol/HDL-cholesterol | 3.47 ± 0.76 | 4.34 ± 0.74 | 0.005 |
| LDL diameter (A) | 254.4 ± 1.9 | 252.4 ± 1.6 | 0.01 |
| Lf (ng/mL) | 555.1 ± 168.9 | 696.2 ± 205.6 | 0.05 |