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. 2016 Nov 30;11(11):e0166690. doi: 10.1371/journal.pone.0166690

Fig 4. Additional immunohistochemical staining of tumor-like lesions in embryonically induced mutant mice suggest similarity to human olfactory neuroblastoma (hONB), but distinctness from human sinonasal haemangiopericytoma (sHPC).

Fig 4

The expression of markers of neuroendocrine differentiation as CD56 and Chromogranin A and positivity for S100 are crucial requirements for the proper diagnosis of hONB and can be detected in OE mouse tumor-like lesions (B, D, F), but are found to be absent in the native mouse OE (A, C, E). SMA is known to be widely diffuse positive in sinonasal haemangiopericytoma but does not homogenously stain cells in our mouse tumor-like lesions (H) or native mouse OE (G). Scale bars equate to 25 μm.