Table 1. Summary of results from Experiment 2.
stereology (SN) | putaminal HPLC (ng/mg protein) | putaminal DAT (nCi/g) | putaminal aSyn | ||||||
---|---|---|---|---|---|---|---|---|---|
condition | TH cell counts | DA | HVA | DOPAC | HVA/DA | DOPAC/DA | (ug/mg protein) | ||
control | mean | 133,717.50 | 92.95 | 99.94 | 5.74 | 1.09 | 0.07 | 657 | 3.08 |
high titer/low volume | mean | 66,630.50 | 26.14 | 61.89 | 2.08 | 6.07 | 0.10 | 202.17 | 3.72 |
% of cntrl | 50 | 28 | 62 | 36 | 558 | 152 | 31 | 121 | |
low titer/high volume | mean | 68,123.50 | 36.96 | 78.52 | 2.18 | 3.14 | 0.07 | 414.03 | 5.14 |
% of cntrl | 51 | 40 | 79 | 38 | 289 | 101 | 63 | 167 |
control, scrA53T aSyn, 5.1 x 1012 gp/ml, 7 μl x 4 sites; high titer, 5.1 x 1012 gp/ml
low titer, 1.7 x 1012 gp/ml; high volume, 28 μl (7 μl x 4 sites); low volume, 20 μl (5 μl x 4 sites); Raw data of the results from Experiments 1 and 2 can be found in S1 Table.