Table 1. TGFβ-signaling target genes with low expression in ADSCs from DSLD-Pasos.
| mRNA Abundance1 | Fold Difference | ||
|---|---|---|---|
| Genes | DSLD Paso | NA Paso | DSLD Paso:NA Paso |
| PTK2B2 | 0.62 | 3.40 | -5.47 |
| ATF3 | 0.67 | 3.32 | -4.93 |
| MAPK14 | 8.95 | 42.98 | -4.80 |
| ME2 | 5.46 | 24.50 | -4.49 |
| ACVRL1 | 0.29 | 1.19 | -4.15 |
| NFIB | 18.82 | 77.71 | -4.13 |
| EPHB2 | 8.93 | 34.93 | -3.91 |
| HMOX1 | 29.83 | 102.5 | -3.44 |
| SMAD6 | 4.90 | 16.01 | -3.27 |
| FOS | 4.37 | 13.90 | -3.18 |
| GLI2 | 0.46 | 1.47 | -3.17 |
| STC2 | 5.65 | 17.36 | -3.07 |
| ID2 | 46.71 | 142.4 | -3.05 |
| PPARA | 2.81 | 8.52 | -3.03 |
| ENG | 39.98 | 120.1 | -3.01 |
| CREBBP | 12.45 | 37.07 | -2.98 |
| NFKBIA | 10.32 | 30.59 | -2.97 |
| BRD2 | 31.83 | 93.94 | -2.95 |
| TGFBR2 | 36.85 | 107.6 | -2.92 |
| MMP2 | 313.7 | 903.0 | -2.88 |
| CDKN1B | 14.11 | 40.49 | -2.87 |
| EP300 | 9.05 | 25.67 | -2.84 |
| FURIN | 1.05 | 2.92 | -2.79 |
| MBD1 | 3.80 | 10.34 | -2.72 |
| IFRD1 | 7.18 | 18.39 | -2.56 |
| SMAD3 | 21.93 | 51.49 | -2.35 |
| BCL2L1 | 5.78 | 13.05 | -2.26 |
| MAPK8 | 4.42 | 9.65 | -2.18 |
| SMAD1 | 8.72 | 18.60 | -2.13 |
| RHOA | 137.6 | 293.5 | -2.13 |
| BACH1 | 9.81 | 20.10 | -2.05 |
| MYC | 33.04 | 65.00 | -1.97 |
| PAI-1 | 351.9 | 686.8 | -1.95 |
| ID3 | 213.64 | 415.4 | -1.94 |
| SNAI1 | 50.64 | 87.37 | -1.73 |
1Mean abundance data for NA-Pasos (n = 5) and DSLD-Pasos (n = 6) is provided (see S1 Table for animal details). Calculation of statistical significance and abundance values are given in the methods Section.
2Genes are listed in order of fold-difference between DSLD-Pasos and NA-Pasos.