Table 1. Antimicrobial susceptibility and biofilm formation ability of Haemophilus influenzae clinical isolates.
Strain | Isolation site | Serotypea | Minimum inhibitory concentration (μg/mL)b | Biofilm formation (OD630) c | P valued | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Ampicillin | Ampicillin sulbactam | Cefotaxime | Clarithromycin | Azithromycin | Levofloxacin | Without OdiE | With OdiE (20 mg/mL) | ||||
2013–28 | Nasal cavity | Nontypeable | 0.125 | 0.125 | ≤0.063 | 2 | 0.25 | ≤0.063 | 0.253 ± 0.061 | 0.096± 0.032 | <0.001 |
2013–86 | Nasal cavity | Nontypeable | 0.25 | 0.25 | ≤0.063 | 4 | 0.5 | ≤0.063 | 0.292 ± 0.047 | 0.098 ± 0.032 | <0.001 |
2011–130 | Nasal cavity | Nontypeable | 8 | 4 | 1 | 2 | 0.125 | ≤0.063 | 0.193 ± 0.025 | 0.104 ± 0.039 | <0.001 |
aSerotype was determined by PCR
bminimum inhibitory concentration was measured by the broth dilution method according to the Clinical and Laboratory Standards Institute guidelines
cmean ± SD
dP values were calculated by the Student's t-test.