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. 2016 Nov 30;11(11):e0167340. doi: 10.1371/journal.pone.0167340

Table 1. Pharmacological effects of piceatannol and resveratrol on in vivo models of renal diseases.

Compound Effects Target organ Animal models References
Piceatannol Mild renoprotective effect Kidney Obese Zucker rats Llarena et al., 2016 [27]
Piceatannol Preventive graft rejection Kidney ACI-to-Lewis rats Fernandez et al., 2002 [26]
Resveratrol • RenoprotectionReduction of renal interstitial fibrosis
• Inhibition of EMT and renal fibrosis
Kidney UUO rats • Yang et al., 2016 [29]
• Zhang et al., 2016 [67]
• Bai et al., 2014 [68]
Resveratrol Attenuation of renal interstitial fibrosis Kidney db/db mice • He et al., 2016 [28]
• Yan et al., 2016 [69]
Resveratrol Amelioration of renal injury and tubulointerstitial fibrosis Kidney SHR rats Xue et al., 2016 [70]
Resveratrol captopril Improvement of aortic remodeling and fibrosis Aorta 2K1C Goldblatt rats Natalin et al., 2016 [71]
Resveratrol • Attenuation of renal injury and fibrosis
• Protective renal fibrosis
Kidney • UUO mice or I/R injury mice
• UUO mice
• UUO mice
• Xiao et al., 2016 [30]
• Liang et al., 2014 [72]
• Li et al., 2010 [48]
Resveratrol Protective renal fibrosis Kidney 5/6th nephrectomized rats Huang et al., 2014 [73]
Resveratrol • Attenuation of diabetic nephropathy
• Reduction of renal fibrosis
Kidney Streptozotocin-treated rats • Wen et al., 2013 [74]
• Chen et al., 2011 [75]
Resveratrol Renoprotection Kidney Unilateral nephrectomized rats Sener at al., 2006 [76]

UUO: unilateral ureteral obstruction

EMT: epithelial-mesenchymal transition

I/R injury: ischemia-reperfusion injury

db/db: spontaneous type 2 diabetic animal model

SHR: spontaneously hypertensive rats

2K1C: two-kidney, one-clip model