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. Author manuscript; available in PMC: 2016 Nov 30.
Published in final edited form as: Vet Immunol Immunopathol. 2016 Apr 19;175:1–6. doi: 10.1016/j.vetimm.2016.04.008

Figure 1. Human cancer cell lines are killed by IL-2 activated porcine NK cells.

Figure 1

PBMCs from SCID and non-SCID piglets incubated in the presence or absence of recombinant human IL-2 (rh IL-2) and tested for cytotoxicity against A375-SM, K562, or PANC-1 human cell lines. Percent Cytotoxicity was reported for 5:1, 10:1, and 20:1 effector:target ratios. SCID PBMCs had the highest percent cytotoxicity (dotted line) compared to non-SCID (NS) littermate cells (solid line). PBMCs not treated (activated) with IL-2, but rather treated with media alone, did not lyse target cells from any of the tumor lines (gray lines).