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Zfp407 overexpression improves glucose homeostasis of high-fat/high-sucrose diet (HFD)-fed mice. WT or ZFP-TG (TG) mice were fed control diet (CD) or HFD beginning at 5 wk of age. After 86 days of CD or HFD feeding, glucose tolerance tests were performed and area under the curve was calculated (A), and insulin tolerance tests were performed (B); n = 7–20/group). Solid line, CD; dashed line, HFD; □, WT; ●, ZFP-TG.
