Table 3.
Metabolic trait data for CD- or HFD-fed 135-day old ZFP-TG and WT female mice.
| CD |
HFD |
3-Way ANOVA (P Value) |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trait | WT | SE | n | ZFP-TG | SE | n | WT | SE | n | ZFP-TG | SE | n | Genotype | Sex | Diet | Interactions |
| Body weight, g | 22.33 | 0.67 | 14 | 19.58 | 0.50 | 11 | 25.47 | 0.91 | 10 | 23.70 | 0.91 | 13 | 3.81e-06 | <2.2e-16 | 9.08e-13 | Sex/diet P = 0.005 |
| Total weight gained, g | 4.70 | 0.46 | 10 | 4.21 | 0.42 | 11 | 8.86 | 0.61 | 13 | 8.01 | 0.65 | 13 | 1.80e-03 | 4.11e-14 | 3.72e-16 | Sex/diet P < 0.001 |
| %Weight gained | 30.42 | 3.54 | 9 | 27.69 | 3.58 | 10 | 53.12 | 3.80 | 13 | 51.93 | 4.65 | 13 | NS | 1.10e-08 | 1.73e-15 | Sex/diet P = 0.006 |
| %Fat mass | 16.67 | 0.38 | 10 | 16.45 | 0.72 | 10 | 21.48 | 1.46 | 10 | 19.38 | 1.69 | 11 | NS | 0.001773 | 3.62e-07 | NS |
| %Lean mass | 83.33 | 0.38 | 10 | 83.55 | 0.72 | 10 | 77.53 | 1.62 | 10 | 79.23 | 1.72 | 11 | NS | 0.01034 | 6.13e-08 | NS |
| Perigonadal fat mass, g | 0.11 | 0.01 | 10 | 0.10 | 0.01 | 10 | 0.24 | 0.06 | 9 | 0.22 | 0.06 | 10 | 0.034161 | 3.77e-08 | 7.08e-08 | Sex/diet P = 0.003 |
| Inguinal fat mass, g | 0.11 | 0.01 | 10 | 0.10 | 0.01 | 10 | 0.23 | 0.04 | 9 | 0.21 | 0.04 | 10 | 0.032657 | 5.23e-06 | 8.42e-09 | Sex/diet P = 0.008 |
| Length, mm | 97.74 | 0.99 | 19 | 94.27 | 0.73 | 11 | 99.00 | 0.60 | 14 | 98.88 | 11.60 | 16 | 0.005326 | 0.002286 | 5.20e-08 | Genotype/diet P = 0.03 |
| Body mass index, kg/m2 | 2.31 | 0.53 | 11 | 2.24 | 0.77 | 11 | 2.69 | 0.76 | 14 | 2.43 | 0.68 | 16 | 5.87e-06 | <2.2e-16 | 4.46e-09 | Genotype/diet P = 0.03 |
| Fasting glucose, mg/dl | 104.71 | 7.66 | 14 | 74.00 | 6.43 | 11 | 113.62 | 7.95 | 13 | 114.57 | 0.65 | 14 | 2.25e-02 | 0.01764 | 1.21e-09 | Genotype/diet P = 0.03 |
| Fasting insulin, ng/ml | 0.26 | 0.06 | 9 | 0.31 | 0.07 | 7 | 0.27 | 0.05 | 9 | 0.22 | 0.06 | 8 | NS | NS | NS | NS |
| HOMA-IR | 1.79 | 0.42 | 9 | 1.65 | 0.34 | 7 | 2.14 | 0.43 | 9 | 1.47 | 0.40 | 8 | NS | 0.01524 | 0.03014 | NS |
| GTT AUC | 24,995 | 937 | 9 | 22,145 | 1,312 | 7 | 29,168 | 2,467 | 9 | 25,336 | 803 | 8 | 0.0008729 | 8.31e-13 | 0.0078087 | NS |
| Plasma β-hydroxybutyrate, mg/dl | 20.23 | 2.23 | 9 | 19.65 | 2.03 | 11 | 17.72 | 1.51 | 10 | 18.90 | 1.62 | 11 | NS | 0.011259 | 0.002899 | NS |
| Plasma cholesterol, mg/dl | 95.44 | 5.06 | 9 | 96.36 | 4.93 | 11 | 109.60 | 7.92 | 10 | 90.00 | 8.29 | 11 | 0.03804 | 2.24e-05 | NS | NS |
| Plasma nonesterified fatty acids, mg/dl | 96.78 | 6.67 | 9 | 91.64 | 3.62 | 11 | 90.70 | 6.89 | 10 | 84.36 | 7.21 | 11 | NS | NS | NS | NS |
| Plasma triglycerides, mg/dl | 0.98 | 0.08 | 9 | 1.26 | 0.19 | 11 | 1.23 | 0.33 | 10 | 0.95 | 0.10 | 10 | 0.008887 | 2.06e-05 | 0.024818 | NS |
| Muscle triglycerides, mg/g tissue | ND | ND | 12.18 | 2.26 | 4 | 15.47 | 2.10 | 5 | NS | ND | ND | ND | ||||
ND, not determined.