Fig. 4.

Hamp disruption ameliorated metaphyseal growth plate alterations caused by adenine-induced CKD. A: safranin O staining of the proximal tibia growth plates in 4 groups of mice; scale bar = 100 μm. B: H&E staining of the proximal tibia growth plates in 4 groups of mice; scale bar = 50 μm. C: growth place height measurements in 4 groups of mice; n = 4 per group; the height of each growth plate was measured by collecting 15–30 measurements along the middle region of each plate. The average measurement coefficient of variation within mice was 14.0% (range 10.4 to 20.7%). Error bars represent between mice SD. **P < 0.01; *** P < 0.001.