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. 2016 Jul 20;311(5):F877–F889. doi: 10.1152/ajprenal.00089.2016

Fig. 7.

Fig. 7.

Effect of adenine-induced CKD and Hamp disruption on systemic inflammation. A: liver mRNA expression of suppressor of cytokine signaling 2 (Socs2) was 5-fold elevated in both CKD(+) groups, WT and HKO, compared with their respective controls. Four liver samples per group were used for PCR. B: serum IL-6 levels were significantly elevated in both CKD(+) groups, WT and HKO, compared with their respective controls, more so in the CKD(+) HKO group. There were no significant differences between WT controls and HKO controls. C: TNF-alpha levels were significantly elevated in both CKD(+) groups, compared with their respective controls. There were no significant differences between WT CKD(−) and HKO CKD(−) controls. D: neutrophilic chemokine (C-X-C motif) ligand 1 (KC-GRO) was highly elevated in CKD(+) HKO, but not in the CKD(+) WT group of mice. Cytokines were measured in n = 5–9 serum samples per group. Error bars represent SD. *P < 0.05; **P < 0.01; ***P < 0.001.