Table 3.
Adenine-induced CKD results in cortical and trabecular bone loss in young mice
| Parameters | Control (n = 7) | CKD (n = 7) | P Value |
|---|---|---|---|
| Cortical bone | |||
| TV, mm3 | 1.86 ± 0.51 | 1.64 ± 0.38 | 0.38 |
| BV, mm3 | 0.81 ± 0.22 | 0.46 ± 0.12 | 0.003 |
| BV/TV, % | 43.3 ± 2.8 | 28.0 ± 1.7 | <0.001 |
| Ct.Po, % | 7.28 ± 1.2 | 11.8 ± 1.17 | <0.001 |
| Ct.Th, mcm | 0.17 ± 0.02 | 0.10 ± 0.007 | <0.001 |
| pMOI, mm4 | 0.37 ± 0.08 | 0.19 ± 0.03 | <0.001 |
| Trabecular bone | |||
| TV, mm3 | 2.61 ± 0.23 | 2.58 ± 0.08 | 0.72 |
| BV, mm3 | 0.44 ± 0.11 | 0.25 ± 0.04 | 0.002 |
| BV/TV, % | 16.6 ± 4.0 | 10.0 ± 1.0 | 0.002 |
| Tb.Th, mm | 0.039 ± 0.005 | 0.030 ± 0.002 | 0.001 |
| Tb.N, 1/mm | 5.68 ± 0.26 | 4.38 ± 0.29 | <0.001 |
| Tb.Sp, mm | 0.17 ± 0.01 | 0.22 ± 0.02 | <0.001 |
| Bs/BV | 68.1 ± 8.4 | 80.9 ± 7.3 | 0.01 |
| Conn.D, 1/mm3 | 387.1 ± 31.5 | 215.3 ± 23.9 | <0.001 |
Values are means ± SD. CKD, chronic kidney disease; TV, total volume; BV, bone volume; Ct.Po, cortical porosity; Ct.Th, cortical thickness; pMOI, polar moment of inertia; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular separation; Bs/BV, bone-specific surface; Conn.D, connectivity/density.