Effects of seizures on core temperature (A), diameter of pial arterioles (B), heart rate (C), and blood pressure (D) in normothermic and head-cooled newborn pigs (N = 6 in each group). For preventive head cooling, head ice packs were placed 30 min before bicuculline administration and kept for the 2-h duration of seizures. A: rectal temperature in normothermic and head-cooled groups. B–D: cerebrovascular and systemic effects of seizures in normothermic and head-cooled groups. Values are means ± SE. *P < 0.05, compared with the normothermic values.