Fig. 8.
Detection of endothelium-dependent cerebral vasodilator functions during delayed postictal period. Cerebral vascular responses to endothelium-dependent vasodilators bradykinin (10−6 M), glutamate (10−4 M), and hemin (10−5 M) were tested in the intact control group (no seizures, N = 8) and in three postictal groups (48 h after seizures). The postictal groups included the normothermia group II (N = 6), the preventive head-cooled group III (head ice packs placed 30 min before seizure onset, N = 6), and the therapeutic head-cooled group IV (head ice packs placed 20 min after seizure onset, N = 6). Values are means ± SE. *P < 0.05 compared with the corresponding intact control values. †P < 0.05 compared with the corresponding normothermic values.