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N6-CPA pretreatment attenuates inflammation in a direct intratracheal endotoxin-induced murine model of ARDS. Mice received 0.1 ml of 100 μM N6-CPA intratracheally 1 h before endotoxin (5 mg/kg) challenge. Lungs were harvested en bloc at 4 (A) and 24 (B) h following endotoxin challenge and then fixed, processed, and stained with hematoxylin and eosin. Photomicrographs are representative images from at least 3 animals per group.
