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Characteristics of the LPS/O2 murine model
| Alterations: LPS/O2 vs. Saline/RA | |
|---|---|
| Increased | Decreased |
| Morphometrics | |
| septal thickness | alveolar number |
| alveolar area | |
| Pulmonary function | |
| tissue resistance | compliance |
| airway resistance | inspiratory capacity |
| Gene expression | |
| vimentin | IkB |
| collagen 1 & 3 | p53 |
| TGFβ | MMP-2 |
| SMAD 2/3 | MMP-3 |
| DNMT 3a and 3b | |
| αSMA | |
These data define the characteristics of the LPS/O2 murine model relevant to the BPD phenotype. RA, room air. See Refs. 1, 19–21.
