Fig. 1.

Profile of bloated mice. Affected mice develop abdominal distention (bloated; A), a rounded posture (B), and stunted growth compared with healthy littermates (C). D: gross findings include enlarged, yellow-orange liver with prominent granular pattern (thin black arrow) filled with lipid, thickened, orange intestines also with a prominent granular pattern (thick black arrow), enlarged spleen (white arrow) and lymph nodes, atrophied pancreas, and decreased adipose tissue, including the absence of an abdominal fat pad. E: body length and weight as well as liver weight were significantly different in bloated animals (open bars) from healthy mice (solid bars). Values are means ± SE; n = 10–20/group. *P ≤ 0.05. **P ≤ 0.01. ***P ≤ 0.001. Liver weight as percent of body weight was 18–26% in affected animals.