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. 2016 Sep 29;311(5):G954–G963. doi: 10.1152/ajpgi.00239.2016

Fig. 7.

Fig. 7.

Effect of SSTR2 and SSTR5 agonist on NHE8 expression in Caco-2 cells. Total cell lysates were prepared from Caco-2 cells and used for Western blot detection of NHE8 protein. A: NHE8 protein expression in Caco-2 cells treated with TNF-α, SST, and seglitide. Data are mean ± SE from 3–5 separate experiments. *P < 0.05 for TNF-α-treated cells (TNF) vs. control (CT), SST-treated cells (TNF + SST), and seglitide + TNF-α-treated cells (TNF + seglitide). B: NHE8 protein expression in Caco-2 cells treated with TNF-α, 50 nM, or 500 nM L-817,818. Data are mean ± SE from 3–5 separate experiments. TNF + L(50): 50 nM L-817,818 treatment in Caco-2 cells for 18 h; TNF + L(500): 500 nM L-817,818 treatment in Caco-2 cells for 1 h. #P < 0.05 for TNF-α-treated cells (TNF) vs. control (CT), SST-treated cells (TNF + SST), and L-817,818-treated cells (TNF + L-817,818). C: NHE8 protein expression in Caco-2 cells treated with TNF-α and L-817,818 for 1 or 18 h. Data are mean ± SE from 3–4 separate experiments. TNF + L(1h): 500 nM L-817,818 treatment in Caco-2 cells for 1 h; TNF + L(18h): 500 nM L-817,818 treatment in Caco-2 cells for 18 h. $P < 0.05 for TNF-α-treated cells (TNF) vs. control (CT), SST-treated cells (TNF + SST), and L-817,818-treated cells (TNF + L).