. Author manuscript; available in PMC: 2017 Dec 1.

Published in final edited form as: J Neurovirol. 2016 Jul 11;22(6):715–724. doi: 10.1007/s13365-016-0437-4

Table 4.

HIV-1 subtype B and C- adjusted levels of cellular chemotaxis and Inflammatory biomarkers in cerebrospinal fluid and serum. None of the differences was statistically significant.

	CSF				Serum
	Subtype B	Subtype C	Diff (95% CI)¹	p²	Subtype B	Subtype C	Diff (95% CI)¹	p²
Cytokines
TNFα	0.25 (0.47)	0.36 (0.54)	−0.07(−0.69,0.55)	0.83	0.97 (0.15)	0.92 (0.23)	0.46 (−0.16, 1.08)	0.14
IFN y	0.28 (0.43)	0.30 (0.46)	0.12 (−0.5,0.74)	0.70	0.18 (0.38)	0.32 (0.53)	−0.53 (−1.15, 0.09)	0.09
IL1β	−0.11(0.04)	−0.10 (0.02)	−0.18 (−0.8,0.44)	0.56	−0.07 (0.12)	−0.10 (0.00)	0.50 (−0.12, 1.12)	0.11
IL-2	0	0.04 (0.13)	−0.45 (−1.07, 0.17)	0.15	0.06 (0.19)	0.11 (0.48)	−0.25 (−0.87, 0.37)	0.42
IL-4	0.64 (0.00)	0.65 (0.00)	−0.20(−0.82, 0.42)	0.51	0.64 (0.12)	0.69 (0.17)	−0.50 (−1.12, 0.12)	0.11
IL-6	0.15 (0.36)	0.14 (0.28)	0.03 (−0.59, 0.65)	0.92	0.06 (0.27)	0.07 (0.34)	0.047 (−0.57, 0.67)	0.88
IL-7	0.28 (0.21)	0.29 (0.22)	0.20 (−0.42, 0.82)	0.52	0.66 (0.39)	0.74 (0.30)	−0.448 (−1.07, 0.17)	0.15
IL-10	0.22 (0.40)	0.31 (0.46)	−0.15 (−0.77, 0.47)	0.63	0.33 (0.47)	0.29 (0.36)	0.16 (−0.46, 0.78)	0.60
Chemokines
IP-10	3.21 (0.71)	3.37 (0.95)	−0.06 (−0.68, 0.56)	0.86	2.90 (0.33)	3.05 (0.27)	−0.06 (−0.68, 0.56)	0.85
MCP-1	3.15 (0.18)	3.15 (0.21)	0.02 (−0.6, 0.64)	0.96	2.77 (0.19)	2.69 (0.24)	0.11 (−0.51, 0.73)	0.73
MIP-1α	1.08 (0.12)	1.11 (0.16)	−0.04 (−0.66, 0.58)	0.89	0.64 (0.33)	0.66 (0.32)	−0.203 (−0.82, 0.42)	0.51
MIP-1β	1.07 (0.23)	1.05 (0.36)	−0.13 (−0.75, 0.49)	0.67	1.78 (0.23)	1.64 (0.31)	0.29 (−0.34, 0.90)	0.37
RANTES	0.52 (0.48)	0.69 (0.77)	−0.21 (−0.83, 0.41)	0.50	4.49 (0.30)	4.50 (0.22)	−0.02 (−0.64, 0.60)	0.96

Groups differences presented as Cohen’s d effect sizes and 95% confidence intervals.

Adjusted for plasma and HIV viral load suppression, and CD4 nadir.