Table 3.
Bumped kinase inhibitor (BKI)-1553 blood levels of infected and treated mice from groups #7 and #8 during continuous dosing in drinking water (mean value was 6.0 µM). These blood samples were taken midway through the study which suggests a steady state phase. One mouse (F) with a measured blood level of 5.79 µM was found to have parasites in the brain by immunohistological examination. The mouse did not show any clinical manifestation of the disease.
| Mouse ID and Plasma Concentration (µM) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Time of sample collection |
A | B | C | D | E | F | G | H | I | J |
| Evening | 5.03 | 8.28 | 9.9 | 6.08 | 6.93 | ND | ND | ND | ND | ND |
| Morning | 6.78 | 4.54 | 8.34 | 5.69 | 4.88 | 5.79 | 3.62 | 6.18 | 2.48 | 4.6 |
ND, not done.