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. 2016 Nov 3;17(9):2474–2487. doi: 10.1016/j.celrep.2016.10.053

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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The Genetics of Cell Counts and Immunoglobulin Level Variation in a General Population

(A) Violin plot representing the distribution of the percentage of variance explained by genetics for the immune traits. A total of 29 T cell subsets versus 27 B cell subsets were analyzed (mean percentages of variance explained by genetics of 29.5 versus 17.7, respectively; Student’s t test, p ≤ 0.05).

(B) Combined Manhattan plot of all cell types. Red dots mark genome-wide significant associations (p ≤ 5e−10). Immune cell types with the strongest association are indicated.

(C) Overview of the association of multiple genomic loci (ccQLTs) and immune cell types. Darkest colors indicate genome-wide significant ccQTLs, while divergence represents the direction of ccQLT effect.