Table 2.

Brain volume change on-study: global and regional deep gray matter

	DMF	noDMT	p value
Thalamus	−0.10 ± 0.28	−0.04 ± 0.34	0.50
Caudate	−0.08 ± 0.12	−0.01 ± 0.15	0.28
Putamen	−0.06 ± 0.22	−0.32 ± 0.28	0.02*
Globus pallidus	−0.04 ± 0.11	−0.04 ± 0.10	1.00
Total DGM	−0.28 ± 0.42	−0.41 ± 0.80	0.69
PBVC	−0.37 ± 0.49	−1.04 ± 0.67	0.005*

Data represent mean ± standard deviation difference between baseline and 1-year follow-up in ml for all variables except for percent whole brain volume change (PBVC), which shows %; DMF dimethyl fumarate; noDMT no disease-modifying therapy; total cerebral deep gray matter (DGM) = thalamus + caudate + putamen + globus pallidus; p values shown are with time between scans as a covariate; *p < 0.05