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. 2016 Nov 30;355:i5745. doi: 10.1136/bmj.i5745

Table 3.

Estimated age standardised incidences (95% confidence intervals)* of thyroid cancer with regional stage by degree of extension and lymph node involvement according to methods of tumour detection, 1999, 2005, and 2008

Lymph node involvement and extrathyroidal extension 1999 2005 2008
Screening Clinical Unknown Screening Clinical Unknown Screening Clinical Unknown
No lymph node involvement:
 Minimal extension 0.09 (0.05 to 0.12) 0.44 (0.36 to 0.52) 0.38 (0.30 to 0.45) 1.76 (1.62 to 1.90) 1.31 (1.19 to 1.43) 0.75 (0.66 to 0.84) 5.53 (5.30 to 5.77) 2.18 (2.03 to 2.33) 1.56 (1.43 to 1.69)
 Gross extension 0.01 (0.00 to 0.02) 0.03 (0.01 to 0.05) 0.01 (0.00 to 0.01) 0.11 (0.08 to 0.15) 0.10 (0.07 to 0.13) 0.00 (0.00 to 0.00) 0.05 (0.03 to 0.08) 0.02 (0.01 to 0.04) 0.02 (0.01 to 0.04)
Subtotal† 0.10 (0.06 to 0.13) 0.47 (0.39 to 0.55) 0.38 (0.31 to 0.45) 1.87 (1.73 to 2.01) 1.41 (1.28 to 1.53) 0.75 (0.66 to 0.84) 5.59 (5.35 to 5.82) 2.20 (2.05 to 2.35) 1.58 (1.46 to 1.71)
Lymph node involvement:
 None 0.13 (0.09 to 0.18) 0.52 (0.43 to 0.60) 0.16 (0.11 to 0.20) 1.33 (1.21 to 1.45) 0.89 (0.79 to 0.99) 0.46 (0.39 to 0.53) 3.05 (2.87 to 3.23) 1.14 (1.02 to 1.25) 0.89 (0.80 to 0.99)
 Minimal extension 0.13 (0.09 to 0.17) 0.53 (0.44 to 0.61) 0.49 (0.41 to 0.57) 1.43 (1.30 to 1.55) 1.46 (1.33 to 1.59) 0.77 (0.68 to 0.86) 5.48 (5.24 to 5.72) 2.06 (1.91 to 2.21) 2.00 (1.86 to 2.15)
 Gross extension 0.01 (0.00 to 0.02) 0.05 (0.03 to 0.08) 0.01 (0.00 to 0.02) 0.12 (0.08 to 0.15) 0.14 (0.10 to 0.19) 0.03 (0.01 to 0.05) 0.04 (0.02 to 0.05) 0.11 (0.08 to 0.15) 0.02 (0.00 to 0.03)
Subtotal‡ 0.27 (0.21 to 0.33) 1.10 (0.98 to 1.22) 0.66 (0.57 to 0.75) 2.87 (2.70 to 3.05) 2.49 (2.32 to 2.66) 1.26 (1.14 to 1.38) 8.56 (8.27 to 8.86) 3.31 (3.12 to 3.50) 2.91 (2.74 to 3.09)
Total 0.37 (0.32 to 0.42) 1.57 (1.46 to 1.68) 1.04 (0.95 to 1.13) 4.74 (4.57 to 4.91) 3.90 (3.74 to 4.06) 2.01 (1.89 to 2.12) 14.15 (13.86 to 14.44) 5.51 (5.33 to 5.70) 4.50 (4.33 to 4.66)

*Calculated per 100 000 population. Segi’s world standard population was used for age standardisation.

†Represents age standardised incidence of regional stage thyroid cancer without regional lymph node involvement.

‡Represents age standardised incidence of regional stage thyroid cancer that involves regional lymph node.