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. Author manuscript; available in PMC: 2017 May 5.
Published in final edited form as: Mol Cell Endocrinol. 2016 Feb 19;426:113–124. doi: 10.1016/j.mce.2016.02.015

Fig. 8.

Fig. 8

Comparison of Fshb−/− HSFHBWT and Fshb−/− HSFHBdgc mice, their interspecies hybrid FSH heterodimer composition, number of N-linked glycans, FSH dimer assembly and secretion characteristics. Genetic rescue of Fshb−/− mice was achieved with HSFHBWT, but not HSFHBdgc transgene, confirming that N-linked glycans of hFSHβ subunit are essential for FSH heterodimer assembly and secretion in vivo. The positions of Asn-linked N-glycans on FSH α (Asn52 and Asn78) – and β -subunits (Asn7 and Asn24) are indicated.