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. 2016 Dec 1;7:459. doi: 10.3389/fphar.2016.00459

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Copyright © 2016 Michalak, Mosińska and Fichna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Derivatives of polyunsaturated fatty acids (PUFA) with anti- and pro-inflammatory properties. In contrast to n-3 PUFA-derived mediators, which are mostly considered as anti-inflammatory, n-6 PUFA derivatives promote inflammatory response. However, one of the unique metabolites of n-6 PUFA are lipoxins (Lx)- LxB4 and LxB5, which display a wide spectrum of anti-inflammatory and pro-resolution actions. AA, arachidonic acid; AEA, N-arachidonoylethanolamide, anandamide; ALA, alpha-linoleic acid; 2-AG, 2-arachidonoylglycerol; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FA, fatty acid; LOX, lipoxygenases; LTB-4, leukotriene B-4; LxA4, lipoxin A4; LxB4, lipoxin B4; PGD2, prostaglandin D2; PGE2, prostaglandin E2; TxA2, thromboxane A2; 12/15 HETE, 12/15 hydroxyeicosatetraenoic acid.