Table 3.

Univariate analysis of the relation between stroke severity, patient characteristics and BBB Permeability values (in penumbra and infarct core), and extraction ratio and BBB Permeability ratio (in infarct core)

Outcome:	BBB Permeability penumbra		BBB Permeability infarct core		Extraction ratio infarct core		BBB Permeability ratio infarct core
Predictor:	B	95 % CI	B	95 % CI	B	95 % CI	B	95 % CI
Age (in years)	− 0.008	− 0.026–0.010	− 0.020	− 0.042–0.003	− 0.197	− 0.633–0.238	− 0.006	− 0.018–0.006
Female sex	− 0.495*	− 0.958 – − 0.032	− 0.786*	− 1.386 – − 0.186	− 11.251	− 22.540–0.038	− 0.097	− 0.428–0.235
NIHSSa	− 0.043	− 0.217–0.131	− 0.007	− 0.238–0.223	2.200	− 2.032–6.432	− 0.081	− 0.204–0.042
Time to scanb	0.008	− 0.097–0.112	0.049	− 0.090–0.188	− 0.260	− 2.794–2.273	0.013	− 0.062–0.087
Cardiovascular risk factors (yes/no)c	0.222	− 0.280–0.725	− 0.065	− 0.726–0.596	2.731	− 9.550–15.012	0.167	− 0.189–0.523
Glucose (mmol/l)	0.064	− 0.083–0.212	0.012	− 0.180–0.204	2.247	− 1.122–5.616	− 0.019	− 0.124–0.085
Dense vessel sign (yes/no)	0.134	− 0.360–0.629	0.374	− 0.256–1.004	7.213	− 4.742–19.167	− 0.188	− 0.526–0.151
Early CT signs (yes/no)	0.232	− 0.247–0.712	0.819*	0.214–1.424	18.709*	7.397–30.020	0.276	− 0.055–0.607
Penumbra size (cm2)	0.003	− 0.009–0.015	0.010	− 0.005–0.026	0.228	− 0.063–0.520	− 0.005	− 0.013–0.004
Infarct size (cm2)	− 0.003	− 0.020–0.013	0.007	− 0.014–0.029	0.463*	0.062–0.864	− 0.003	− 0.014–0.009

^aIn 5 categories: 1–3, 4–6, 7–12, 13–17 and 18 or higher

^bIn 4 categories: 0–3, 3–4, 5 4.5–6 and 6–9 h

^cAny from: hyperlipidemia, hypertension, diabetes, angina pectoris, myocardial infarction or atrial fibrillation

*P < 0.05