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. 2016 Dec 1;6:38254. doi: 10.1038/srep38254

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Copyright © 2016, The Author(s)

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On the one hand, IFNs binds to IFNR and stimulates STAT1, whereas up-regulated STAT1 promotes the expression of CCLs and regulates uterus receptive through IRF9 and the downstream targets IFITs, MXs, OAS. However, GSTM2 could bind to STAT1 and suppress the phosphorylation of STAT1. Hence, the high expression of these IFNGs which was regulated by STAT1 would be balanced by GSTM2, so that the uterus receptive was promoted. On the other hand, GSTM2 regulates OPN through SRC and ER, furthermore, OPN binds to integrin to regulate conceptus development through PI3K-AKT-mTORC signaling. GSTM2 could also promote conceptus development by up-regulating expression of SLCs and increasing the AA and glucose into embryo.