Table 1. Demographical and clinical characteristics of retrospective cohort and their association with HCC.
| Characteristics | Participants, number (%) | Follow-up, person-years | HCC, number | Hazard ratio (95% confidence interval) | P value |
|---|---|---|---|---|---|
| Age at entry, y | |||||
| <30 | 692 (30.6) | 4581.8 | 8 | 1.00 [Reference] | |
| 30–39 | 941 (41.6) | 6204.1 | 20 | 1.84 (0.81–4.18) | 0.14 |
| 40–49 | 433 (19.1) | 2762.6 | 18 | 3.81 (1.66–8.77) | 0.002 |
| ≧50 | 196 (8.7) | 1208.0 | 16 | 7.95 (3.40–18.60) | <0.001 |
| Sex | |||||
| Female | 552 (24.4) | 3541.5 | 11 | 1.00 [Reference] | |
| Male | 1710 (75.6) | 11215.0 | 51 | 1.44 (0.75–2.76) | 0.28 |
| Cirrhosis | |||||
| Non-cirrhosis | 1180 (52.2) | 7863.8 | 2 | 1.00 [Reference] | |
| Cirrhosis without ascites | 937 (41.4) | 5975.3 | 46 | 31.26 (7.59–128.82) | <0.001 |
| Cirrhosis with ascites | 145 (6.4) | 917.4 | 14 | 62.38 (14.17–274.51) | <0.001 |
| APRI at the end | |||||
| <0.5 | 1111 (55.1) | 7335.9 | 12 | 1.00 [Reference] | |
| 0.5–1.5 | 732 (36.3) | 4776.9 | 27 | 3.47 (1.76–6.85) | <0.001 |
| >1.5 | 174 (8.6) | 1064.2 | 20 | 12.10 (5.91–24.77) | <0.001 |
| Persistence of elevated TBA | |||||
| None-low | 1773 (78.4) | 11690.3 | 25 | 1.00 [Reference] | |
| Medium | 267 (11.8) | 1686.7 | 13 | 3.70 (1.89–7.22) | <0.001 |
| High | 222 (9.8) | 1379.5 | 24 | 8.60 (4.91–15.06) | <0.001 |
| Persistence of elevated ALT | |||||
| None-low | 1435 (63.4) | 9357.4 | 28 | 1.00 [Reference] | |
| Medium | 589 (26.0) | 3892.3 | 21 | 1.78 (1.01–3.14) | 0.04 |
| High | 238 (10.5) | 1506.8 | 13 | 2.93 (1.52–5.66) | 0.001 |
| Persistence of elevated HBV DNA | |||||
| None-low | 1807 (79.9) | 11856.6 | 48 | 1.00 [Reference] | |
| Medium | 316 (14.0) | 2020.5 | 10 | 1.25 (0.63–2.47) | 0.52 |
| High | 139 (6.2) | 879.4 | 4 | 1.16 (0.42–3.23) | 0.77 |
| Baseline HBeAg | |||||
| Negative | 1155 (51.1) | 7592.4 | 44 | 1.00 [Reference] | |
| Positive | 1107 (48.9) | 7164.1 | 18 | 0.44 (0.25–0.76) | 0.003 |