Table 3. Multivariate analyses of risk for HCC.

Characteristics	HCC, number (%)	Hazard ratio (95% confidence interval)	P value
Age at entry in 1-year increment		1.03 (1.00–1.06)	0.027
Sex
Female	11 (18.6)	1.00 [Reference]
Male	48 (81.4)	1.17 (0.58–2.39)	0.66
Cirrhosis
Non-cirrhosis	2 (3.4)	1.00 [Reference]
Cirrhosis without ascites	43 (72.9)	17.01 (3.96–73.15)	<0.001
Cirrhosis with ascites	14 (23.7)	15.42 (3.20–74.32)	0.001
APRI at the end
<0.5	12 (20.3)	1.00 [Reference]
0.5–1.5	27 (45.8)	1.60 (0.78–3.27)	0.20
>1.5	20 (33.9)	2.67 (1.12–6.38)	0.027
Persistence of elevated TBA
None-low	23 (39.0)	1.00 [Reference]
Medium	13 (22.0)	2.37 (1.16–4.84)	0.018
High	23 (39.0)	2.57 (1.28–5.16)	0.008
Persistence of elevated ALT
None-low	28 (47.4)	1.00 [Reference]
Medium	18 (30.5)	1.26 (0.67–2.39)	0.47
High	13 (22.0)	1.82 (0.86–3.90)	0.12
Persistence of elevated HBV DNA
None-low	45 (76.3)	1.00 [Reference]
Medium	10 (16.9)	1.62 (0.78–3.35)	0.19
High	4 (6.8)	3.14 (1.02–9.64)	0.045
Baseline HBeAg
Negative	43 (72.9)	1.00 [Reference]
Positive	16 (27.1)	0.61 (0.33–1.13)	0.12