Figure 6. Serum and pulmonary cytokine secretion following B. pertussis challenge in mice immunized with omvPV or wPV and non-immunized mice.
(A,B) The concentrations of 32 cytokines were determined prior to and at multiple time points post challenge with B. pertussis in non-immunized mice (green) or mice immunized with omvPV (red) or wPV (blue). Only cytokines that were significantly altered in (A) serum and (B) lung lysate are depicted. Data are presented as mean ± SD for immunized groups (n = 4) and non-immunized groups (n = 3). *p ≤ 0.05 for challenged groups vs. day 56, #p ≤ 0.05 for immunized groups vs. non-immunized group, +p ≤ 0.05 for omvPV group vs. wPV group.