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. 2016 Nov 16;1(5):952–962. doi: 10.1021/acsomega.6b00126

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Copyright © 2016 American Chemical Society

This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.

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Viability of LNCaP cells in 3D spheroid cultures. (A) Docetaxel-encapsulated, targeted polymersomes (purple bar) were more potent compared to the free drug (orange bar), targeted vesicles without any drug (green bar), nontargeted polymersomes without any drug (pink bar), and the media (cyan bar). (B) Mocetinostat-encapsulated, targeted polymersomes (purple bar) were more potent compared to the free drug (orange bar), targeted vesicles without any drug (green bar), nontargeted polymersomes without any drug (pink bar), and the media (cyan bar). (C) The combination of docetaxel/mocetinostat-encapsulated targeted polymersomes (purple bar) was more potent compared to the free drug (orange bar), targeted vesicles without any drug (green bar), nontargeted polymersomes without any drug (pink bar), and the media (cyan bar). Data presented are representative of three individual experiments. Error bars denote the mean ± SEM. Statistical analysis: Student’s t-test where *p < 0.05, **p < 0.001, and ***p < 0.0001.