Viability of the LNCaP cells in monolayer cultures. (A) Cell viability
with media only (control, cyan bar), nontargeted polymersomes (pink
bar), nontargeted polymersomes encapsulating docetaxel (red bar),
targeted polymersomes (green bar), free docetaxel (orange bar), and
targeted polymersomes encapsulating docetaxel (purple bar). (B) Cell
viability with media only (control, cyan bar), nontargeted polymersomes
(pink bar), nontargeted polymersomes encapsulating mocetinostat (red
bar), targeted polymersomes (green bar), free mocetinostat (orange
bar), and targeted polymersomes encapsulating mocetinostat (purple
bar). (C) Cell viability with media only (control, cyan bar), nontargeted
polymersomes (pink bar), nontargeted polymersomes encapsulating docetaxel/mocetinostat
(red bar), targeted polymersomes (green bar), free docetaxel and mocetinostat
(orange bar), and the combination of targeted polymersomes encapsulating
docetaxel/mocetinostat (purple bar). The data presented are representative
of three individual experiments. Error bars denote the mean ±
SEM. Statistical analysis: Student’s t-test
where *p < 0.05, **p < 0.001,
and ***p < 0.0001.