Figure 5. Foldability coloring of the complement factor H sushi domains.

High-foldability residues are considered critical and are colored in red. Low-foldability residues are shown in blue. (a) The sushi domains are superimposed based on their structural alignment. (b) Structural alignment of β-strands in the 20 aligned sushi domains. (c) A side view of sushi domain 5 with the side chains of the residues. The critical residues are concentrated towards the hydrophobic core. The foldability coloring was obtained in the program Chimera using the Python script described in the Methods section.