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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Cell Rep. 2016 Nov 15;17(8):2028–2041. doi: 10.1016/j.celrep.2016.10.068

Figure 4. Reducing 3TF expression attenuates inflammation and promotes A→β reprogramming.

Figure 4

(A) mCherry fluorescence in the pancreas of 3TF mice administered either 0.02, 0.2, or 2.0 mg/ml of dox for 7 days. (B) Quantification of fluorescence intensity per pancreas area. Data are represented as mean ± SEM. *p < 0.05, student’s t-test. (C) Pancreatic immunofluorescence CD45 staining of 3TF mice administered varying concentrations of dox at 7 days. (D) Percentage of CD45+ cells among DAPI+ cells. Three mice per time point and over 1,000 DAPI+ cells counted for each mouse. Data are represented as mean ± SEM. *p < 0.05, student’s t-test (E) Pancreatic immunofluorescence insulin staining of 3TF mice administered 0.2 mg/ml of dox for 7 days. mCherry+ cells that co-expressed insulin (arrows) were observed. (F) Percentage of insulin+ cells among mCherry+ cells. Three mice per time point and over 500 mCherry+ cells counted for each mouse. Data are represented as mean ± SEM. See also Figure S6.