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. 2016 Dec 1;6:37907. doi: 10.1038/srep37907

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The simulated distributions of the rate of bacterial population growth/decline for three Pasteurella multocida isolates: (a) isolate with enrofloxacin MIC = 0.01 μg/mL; (c) isolate with enrofloxacin MIC = 1.5 μg/mL; and (e) isolate with enrofloxacin MIC = 2.0 μg/mL. The resulting bacterial density after 1-hour exposure to different enrofloxacin concentrations, with the starting density 5 × 10⁵ CFU/mL, for three Pasteurella multocida isolates: (b) isolate with enrofloxacin MIC = 0.01 μg/mL; (d) isolate with enrofloxacin MIC = 1.5 μg/mL; and (f) isolate with enrofloxacin MIC = 2.0 μg/mL. In each panel or box-plot, the outputs of 1,000 simulations for each enrofloxacin concentration of the best-fit pharmacodynamic model for the isolate are summarized. CFU – colony forming units.