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. 2016 Dec 1;16:169. doi: 10.1186/s12890-016-0331-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Development of hypoxemia is associated with worsened QOL and reduced exercise tolerance. Compared to normoxic participants at Phase 2, participants who developed hypoxemia had a greater rate of change in a SGRQ total score, b SGRQ activity score, c SGRQ impact score, but no difference of change in d SGRQ symptom score or breathlessness measured by e MMRC. Likewise, these participants have a greater decrease in f 6MWD change compared to participants who remained normoxic. Error bars represent standard error. SGRQ = St George’s Respiratory Questionnaire, 6MWD = 6-min walk distance. MMRC = modified medical research council score. *P < 0.05, **P < 0.01, ***P < 0.001