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. 2016 Nov 30;17:78. doi: 10.1186/s12868-016-0317-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Histopathology of the spinal cord of sham-immunized and MOG-immunized animals. Inflammation (ED1) as well as demyelination start in the lumbar part of the spinal cord and propagates toward the cervical area. There are no histopathological changes detectable in the preclinical phase of EAE. Circles represent values for one individual animal