Table 4.
Radiological and serological results of TSOL+ individuals of the matched and initially recruited population
P 1 | P 2 | P 3 | P 4 | P 5 | P 6 | P 7 | P 8 | P 9 | P 10 | |
---|---|---|---|---|---|---|---|---|---|---|
Matched study group | yes | yes | yes | yes | yes | yes | yes | yes | no | no |
Age | 50 | 46 | 45 | 60 | 46 | 28 | 27 | 51 | 38 | 14 |
Gender | f | m | m | m | m | f | f | m | m | m |
First clinical examination | ||||||||||
HIV parameters | ||||||||||
HIV status | + | + | + | + | - | - | - | - | - | - |
HIV stage | I | I | I | III | - | - | - | - | - | - |
HAART drugs | ZDV/3TC/EFZ | ZDV/3TC/EFZ | ZDV/3TC/EFZ | ZDV/3TC/EFZ | - | - | - | - | - | - |
HAART treatment since (years) | <1 | 3 | 3 | 4 | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. |
NCC symptoms/signs | - | - | - | headaches | - | severe headaches | - | - | epi | epi, enca |
CT diagnosis | ||||||||||
Calcified cysts | + | - | + | + | o | o | o | o | + | - |
Viable cysts | - | - | - | - | o | o | o | o | - | + |
Other NCC relevant findings | - | - | - | - | o | o | o | o | - | hydrocephalus |
Laboratory diagnosis | ||||||||||
CD4+ counts | 554 | 433 | 276 | 170 | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. |
CC- Ab | + | + | + | + | + | + | + | + | + | + |
CC-Ag | - | - | - | + | - | - | - | - | - | + |
Taeniosis-Ab | + | - | - | - | - | - | + | + | + | + |
Second clinical examination | ||||||||||
NCC symptoms/signs | x | x | - | - | - | severe headaches | - | x | d | epi, enca |
CT diagnosis | x | |||||||||
Calcified cysts | x | x | + | + | + | - | + | x | d | + |
Viable cysts | x | x | - | - | - | - | - | x | d | + |
Other NCC relevant findings | x | x | - | - | - | hydrocephalusb | - | x | d | hydrocephalus |
Laboratory findings | ||||||||||
CD4+ counts | 521 | 400 | 368 | 184 | n.a. | n.a. | n.a. | n.a. | d | n.a. |
CC-Ab | + | + | - | - | + | x | x | x | d | x |
CC-Ag | - | - | - | + | - | x | x | x | d | x |
Taeniosis-Ab | + | - | - | - | - | x | x | x | d | x |
Taeniosis-copro-Ag | - | - | - | - | - | - | - | x | d | x |
P patient number, m male, f female, HIV human immunodeficiency virus, HAART highly active antiretroviral therapy, ZDV zidovudine, 3TC lamivudine, EFZ efavirenz, NCC neurocysticercosis, epi epilepsy, enc encephalopathy, CT computed tomography, CD4 + CD4+ T-lymphocyte cell counts, n.a. not applicable, because in the group of HIV– these parameters were not tested and no HAART was taken, CC cysticercosis, Ab antibodies, Ag antigen, + positive, − negative, o was not taken at once due to ethical concerns of performing a CT scan in healthy individuals, but was offered when the positive test serology was confirmed, x patient refused or was not found, d patient died before 2nd examination with unclear diagnosis (strong headaches and abdominal pain reported before death)
aPatient was unconscious with signs of brainstem involvement and generalized increased muscle tone leading to flexion contractures of all four limbs, most likely in the context of increased intracranial pressure
bMass in 4th ventricle causing obstructive hydrocephalus