Table 2.
Age-related changes of the expression of the selected miRNAs in human peripheral blood mononuclear cells
| Expression arbitrary units [median value (25th, 75th percentile)] | P-value | |||||
|---|---|---|---|---|---|---|
| miRNA | Ya | Eb | Lc | Y vs. E | E vs. L | Y vs. L |
| miR-9 | 0.39 (0.16, 0.82) | 0.54 (0.16, 1.13) | 0.96 (0.27, 1.40) | p = 766 | p = 0.381 | p = 0.021 |
| miR-96 | 0.29 (0.10, 0.53) | 0.75 (0.22, 2.06) | 0.74 (0.23, 2.52) | p = 0.009 | p = 1 | p = 0.006 |
| miR-99a | 2.42 (1.16, 4.83) | 1.23 (0.53, 2.59) | 1.50 (0.83, 3.41) | p = 0.038 | p = 1 | p = 0.265 |
| miR-132 | 0.21 (0.08, 0.41) | 0.21 (0.11, 0.41) | 0.25 (0.12, 0.50) | p = 1 | p = 1 | p = 1 |
| miR-145 | 0.14 (0.07, 0.47) | 0.13 (0.06, 0.34) | 0.27 (0.13, 0.57) | p = 1 | p = 0.029 | p = 0.104 |
| miR-182 | 0.18 (0.10, 0.47) | 0.21 (0.06, 1.02) | 0.23 (0.09, 1.55) | p = 1 | p = 0.752 | p = 0.292 |
a: young (Y), b: elderly (E), c long-lived (L) individuals
Significant p-values are shown in bold