Table 1.
Expected functions of cellular proteins related to mutations by GO directly produced in DNA
Protein | Role | |
---|---|---|
Specialized DNA pol | ||
pol η | error-free bypass | |
pol ζ | error-free bypass | |
pol κ | error-prone bypass | |
pol λ | error-free bypass, suppression of untargeted mutations | |
DNA glycosylase | ||
OGG1 | suppression of G→T mutation by GO removal | |
MUTYH | suppression of G→T mutation by A removal | |
NTH1 | suppression of G→T mutation | |
NEIL1 | suppression of G→T mutation | |
WRN | suppression of untargeted mutations |