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. 2016 Dec 1;6:38108. doi: 10.1038/srep38108

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Copyright © 2016, The Author(s)

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(A,B) Rare Nav1.6 is colocalized with nestin in the CA1 and CA3 subregions in the hippocampus in the controls. (C,D) Nav1.6 is highly colocalized with nestin in the CA1 and CA3 subregions in the ipsilateral hippocampus at 21 days after-SE in KA induced TLE rats. (E,F) Note Nav1.6-ir is extensively distributed in the soma and process of nestin-ir positive cells in the ipsilateral hippocampus at 21 days after-SE in KA induced TLE rats at high magnification. The colocalization ratios of Nav1.6 with nestin in the hippocampal CA1 and CA3 subregions in KA induced TLE rats and the controls are shown in G and H. Data are plotted as mean ± SEM of five animals in each group. SO: stratum oriens; SR: stratum radiatum; SL: stratum lucidum; SP: stratum pyramidale. *P < 0.05, **P < 0.01, significantly different from the control animals.