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. 2016 Dec 1;15:579. doi: 10.1186/s12936-016-1625-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Parasitaemia inhibition and survival of mice treated with different doses of 21A. Five BALB/c mice per group were infected with P. berghei ANKA. The mice were treated with three daily doses of 100, 75, 50 or 25 mg/kg of 21A starting at day-3 post infection. The positive and negative control mice were given three daily doses of 30 mg/kg chloroquine and 10% DMSO, respectively. a Per cent parasitaemia. The graph is the mean parasitaemia and standard error of the mean (SEM) of five mice in a group, and b Kaplan–Meier survival plot of mice treated with different doses of 21A and controls. Asterisk indicates a statistically significant difference between the drug treated mice and the vehicle control group (DMSO)