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. 2016 Dec 1;14:332. doi: 10.1186/s12967-016-1090-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Mixed meal tolerance test performed at the 24th month of follow-up. Levels of C-peptide in MMTT in T1DM children at the 24th month of follow-up are displayed separately for untreated controls (NO tregs), patients treated with single infusion of Tregs (single dose) and patients treated with two infusions of Tregs (two doses). The values are given as medians (min.–max.) and the legend shows the timing of C-peptide measurements in minutes during the test. The horizontal lines represent significant differences (p < 0.05) in C-peptide levels in Kruskal–Wallis ANOVA between the untreated group and the group treated with two doses of Tregs in all ten time points of the test