Fig. 4.

Subsets of tregs in the follow-up. a The ratio between Tcm and Tn CD3+ CD4+ FoxP3+ Tregs is shown to better visualize the Tcm/Tn swap. b The percentages of Tn Tregs (upper panel), Tcm Tregs (middle panel), and Tem Tregs (bottom panel). The values for untreated controls (NO Tregs), patients treated with single infusion (single dose), and patients treated with two infusions (two doses) during the follow-up. Data are presented as medians (min.–max.), and the open circles represent particular patients. The *p values represent the significance in Kruskal–Wallis ANOVA comparisons between three groups at the 24th month; p values and short lines represent the significance of Wilcoxon test comparisons immediately after Tregs infusions in the treated groups; p values and long lines represent the significance of Wilcoxon test comparisons between day-10 or day 0 vs. the 24th month in particular groups